Research on the Greek Orthodox medico-philosophers (combining the expertise of both a medical doctor and a philosopher) in the early modern period must consider their great mobility outside the Ottoman Empire. A classic trajectory included pursuing medical studies in Western Europe and then moving to Russia, which offered them many employment opportunities. One such example is Damianus Paraskevas Sinopeus (1687-1776), who studied medicine in Germany and practised it at the highest level in Russia for many decades. While in Germany, he also published three philosophical treatises in Latin defending the philosophy of Christian Wolff (1679-1754) and participated in a creative way in the intellectual debates of the Western European world. He therefore enjoyed wider recognition at the time, because he contributed to the productive contacts between East and West in the context of an inclusive Republic of Letters across the whole European continent.